Amylyx Pharmaceuticals, Inc.

Amylyx Pharmaceuticals, Inc.

Healthcare

NASDAQ:AMLX · NASDAQ Global Select

Market Cap $1.21B Beta -0.16 P/E (TTM) -10.7
$14.59 +4.89%

+$0.68 today

52W Low $4.80High $18.61

Vol 1.45M · Avg 1.13M

EPS (TTM)-$1.36
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-47.4%

avg -13.9%

ROIC

-49.3%

avg 11.2%

ROA

-43.5%

avg -154.8%

Analysis

ROA is currently the strongest return metric at -43.5% versus its period average of -154.8%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Justin Klee

Co-CEO & Director$1.25M35$3.58M4.31%

Joshua Cohen

Co-Founder, Co-CEO & Director$1.25M34$3.58M4.31%

Camille L. Bedrosian

Chief Medical Officer$1.01M73$265,285.000.32%

James Frates

Chief Financial Officer$817,183.0059$261,628.000.31%

Gina Mazzariello

Chief Legal Officer & General Counsel$715,494.0054$209,090.000.25%

Jamie Timmons

Head of Global Medical Strategy & Communications

Machelle Manuel

Vice President & Head of Global Medical Affairs

Dan Monahan

Chief Commercial Officer

Tom Holmes

Chief Technical Operations Officer

Linda A. Arsenault

Chief Human Resources Officer

Lindsey Allen

Head of Investor Relations & Communications

Tammy Sarnelli

Global Head of Regulatory Affairs

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

2

$152,183.00

Sells

27

$7.39M

Net Sentiment

$7.23M

Net selling

Most Active

Klee Justin B.

7 transactions

DateInsiderTypeSharesPriceValue
May 21, 2026

Firestone Karen

Direct

Buy3.8K$13.51$51,338.00
Mar 2, 2026

Klee Justin B.

Direct

Sell29.3K$14.47$423,760.32
Mar 2, 2026

Cohen Joshua B

Direct

Sell29.3K$14.48$424,120.49
Mar 2, 2026

Bedrosian Camille L

Direct

Sell6.5K$14.58$94,205.26
Mar 2, 2026

FRATES JAMES M

Direct

Sell7.9K$14.52$114,851.33
Mar 2, 2026

Mazzariello Gina

Direct

Sell6.8K$14.52$99,378.30
Feb 23, 2026

Mazzariello Gina

Direct

Sell3.4K$14.14$48,352.18
Feb 2, 2026

FRATES JAMES M

Direct

Sell3.6K$14.65$52,096.89
Feb 2, 2026

Cohen Joshua B

Direct

Sell15.5K$14.68$227,592.70
Feb 2, 2026

Mazzariello Gina

Direct

Sell3.4K$14.65$50,515.61

1–10 of 29

Analysis

Insiders reported 2 buys worth $152,183.00 and 27 sells worth $7.39M over the last 12 months. That adds up to net selling of $7.23M. Klee Justin B. was the most active insider with 7 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
+15.7% (7yr)2 analysts
RevenueN/AN/A+736.7%
+5.1% (7yr)7 analysts
Net IncomeN/AN/AN/A
+20.7% (7yr)7 analysts
EBITN/AN/AN/A
-16.5% (7yr)7 analysts

Analysis

Recent growth has been strongest in Revenue at +736.7% over three years. Forward estimates point to Net Income at +20.7% (7yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages AMLX?

Amylyx Pharmaceuticals, Inc. (AMLX) lists 12 active executives. The top listed executive is Justin Klee, Co-CEO & Director.

Are AMLX insiders buying or selling?

Recent insider activity shows net buying of $15.17M.

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