Denali Therapeutics Inc.

Denali Therapeutics Inc.

Healthcare

NASDAQ:DNLI · NASDAQ Global Select

Market Cap $3.44B Beta 1.01 P/E (TTM) -8.0
$21.66 +3.04%

+$0.64 today

52W Low $12.58High $23.77

Vol 2.17M · Avg 1.80M

EPS (TTM)-$2.72
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-50.6%

avg -14.2%

ROIC

-52.6%

avg -28.7%

ROA

-44.8%

avg -24.0%

Analysis

ROA is currently the strongest return metric at -44.8% versus its period average of -24.0%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Ryan J. Watts

Co-Founder, President, Chief Executive Officer & Director$1.42M50$296,833.000.19%

Alexander O. Schuth

Co-Founder, Chief Financial Officer, Chief Operating Officer & Secretary$926,175.0053$282,828.000.18%

Katie Peng

Chief Commercial Officer55

Joe Lewcock

Chief Scientific Officer

Cindy Dunkle

Chief People Officer

Chris Walsh

General Counsel

Dana Andersen

Chief Technical and Manufacturing Officer

Peter Chin

Acting Chief Medical Officer & Head of Development58$33,941.000.02%

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

2

$22,857.14

Sells

6

$8.39M

Net Sentiment

$8.36M

Net selling

Most Active

Watts Ryan J.

2 transactions

DateInsiderTypeSharesPriceValue
Jan 6, 2026

Watts Ryan J.

Direct

Sell35.2K$16.50$580,767.00
Jan 6, 2026

Schuth Alexander O.

Direct

Sell17.2K$16.50$284,097.00
Dec 11, 2025

BAKER BROS. ADVISORS LP

Indirect

Buy2.10M$0.01$20,951.91
Dec 11, 2025

BAKER BROS. ADVISORS LP

Indirect

Buy190.5K$0.01$1,905.23
Aug 13, 2025

Ho Carole

Direct

Sell806$14.64$11,799.84
Aug 12, 2025

Ho Carole

Direct

Sell2.9K$13.58$39,884.46
Aug 12, 2025

Schuth Alexander O.

Direct

Sell2.9K$13.58$39,884.46
Jul 9, 2025

Watts Ryan J.

Direct

Sell495.3K$15.00$7,429,230.00

Analysis

Insiders reported 2 buys worth $22,857.14 and 6 sells worth $8.39M over the last 12 months. That adds up to net selling of $8.36M. Watts Ryan J. was the most active insider with 2 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A5 analysts
RevenueN/AN/AN/A
+37.0% (11yr)7 analysts
Net IncomeN/AN/AN/A
N/A7 analysts
EBITN/AN/AN/A
N/A7 analysts

Analysis

Forward estimates point to Revenue at +37.0% (11yr), giving you a quick read on expected growth from here.

Who manages DNLI?

Denali Therapeutics Inc. (DNLI) lists 8 active executives. The top listed executive is Katie Peng, Chief Commercial Officer.

Are DNLI insiders buying or selling?

Recent insider activity shows net buying of $16.51M.

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