Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Healthcare

NASDAQ:IONS · NASDAQ Global Select

Market Cap $12.11B Beta 0.37 P/E (TTM) -37.0
$73.28 -0.74%

-$0.55 today

52W Low $34.78High $86.74

Vol 1.84M · Avg 1.86M

EPS (TTM)-$1.98
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-77.9%

avg -38.2%

ROIC

-12.0%

avg -5.7%

ROA

-10.8%

avg -6.0%

Analysis

ROA is currently the strongest return metric at -10.8% versus its period average of -6.0%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Brett Monia

Founder, Chief Executive Officer & Director$3.47M65$242,662.000.15%

Elizabeth L. Hougen

Executive Vice President of Finance & Chief Financial Officer$1.60M64$16,348.00<0.01%

Richard S. Geary

Strategic Consultant$1.33M68$59,657.000.04%

Brian Birchler

Executive Vice President of Corporate & Development Operations$1.24M60$67,500.000.04%

Eric E. Swayze

Executive Vice President of Research$1.23M60$32,361.000.02%

Patrick R. O'Neil

Executive Vice President, Chief Legal Officer, General Counsel & Corporate Secretary$1.21M52$72,359.000.04%

Kyle Jenne

Executive Vice President & Chief Global Product Strategy Officer$804,966.0049$23,713.000.01%

C. Frank Bennett

Executive Vice President & Chief Scientific Officer$651,639.0069$165,643.000.10%

Sujit K. Basu

Vice President & Head of Pharmaceutical Development

Jonathan J. Birchall

Senior VP & Chief Commercial Officer56$7,940.00<0.01%

Eugene Schneider

Executive Vice President, Chief Clinical Development & Operations Officer53$63,890.000.04%

Rachel Carnes

Senior Vice President of Global Product Strategy

Roger Lane

Senior Vice President of Clinical Development

Darren Gonzales

Chief Accounting Officer & Senior Vice President

D. Wade Walke

Senior Vice President of Investor Relations

Cliff Ford

Senior VP of Intellectual Property

Hala Mirza

Senior Vice President of Corporate Affairs & Patient Advocacy

Tracy Berns

Senior Vice President and Chief Compliance & Quality Assurance Officer

Charles G. Asare

Vice President & Head of Drug Safety

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

66

$68.48M

Net Sentiment

$68.48M

Net selling

Most Active

Baroldi Joseph

9 transactions

DateInsiderTypeSharesPriceValue
Jun 1, 2026

BERTHELSEN SPENCER R

Direct

Sell8.0K$75.67$605,360.00
May 14, 2026

Monia Brett P

Direct

Sell3.2K$78.68$253,347.35
May 13, 2026

Monia Brett P

Direct

Sell1.3K$78.01$102,665.11
May 4, 2026

LOSCALZO JOSEPH

Direct

Sell17.8K$75.58$1,343,934.21
May 4, 2026

LOSCALZO JOSEPH

Direct

Sell59.5K$74.90$4,457,292.02
May 1, 2026

KLEIN JOSEPH III

Direct

Sell1.4K$74.45$106,534.23
May 1, 2026

KLEIN JOSEPH III

Direct

Sell8.7K$73.35$636,704.04
Apr 28, 2026

Baroldi Joseph

Direct

Sell1.6K$71.79$116,726.80
Apr 16, 2026

Baroldi Joseph

Direct

Sell5.6K$74.56$418,952.64
Apr 16, 2026

Birchler Brian

Direct

Sell973$75.04$73,015.87

1–10 of 66

Analysis

Insiders reported 0 buys worth $0.00 and 66 sells worth $68.48M over the last 12 months. That adds up to net selling of $68.48M. Baroldi Joseph was the most active insider with 9 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A12 analysts
RevenueN/AN/A+40.6%
+18.7% (15yr)9 analysts
Net IncomeN/AN/AN/A
N/A9 analysts
EBITN/AN/AN/A
N/A9 analysts

Analysis

Recent growth has been strongest in Revenue at +40.6% over three years. Forward estimates point to Revenue at +18.7% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages IONS?

Ionis Pharmaceuticals, Inc. (IONS) lists 19 active executives. The top listed executive is Sujit K. Basu, Vice President & Head of Pharmaceutical Development.

Are IONS insiders buying or selling?

Recent insider activity shows net selling of $66.78M.

Explore More

Continue the stock analysis

Jump to another research area for this company.