OnKure Therapeutics, Inc.

Healthcare

NASDAQ:OKUR · NASDAQ Global Market

Market Cap $58.13M Beta 0.28 P/E (TTM) -1.0
$4.36 -1.18%

-$0.05 today

52W Low $1.91High $5.38

Vol 0.12M · Avg 0.34M

EPS (TTM) -$4.30Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management
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ROE

-105.9%

avg -8.1%

ROIC

-110.9%

avg -106.3%

ROA

-95.8%

avg -81.0%

Analysis

ROA is currently the strongest return metric at -95.8% versus its period average of -81.0%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Nicholas A. Saccomano

President, Chief Executive Officer & Director$858,000.0067$110,000.000.80%

Samuel Agresta

Chief Medical Officer$640,600.0053$110,000.000.80%

Jason A. Leverone

Chief Financial Officer$591,200.0052$110,000.000.80%

Isaac Manke

Senior VP of Business Development & Director$60,497.0049$20,583.000.15%

James Blake

Senior Vice President of Computational Drug Discovery

Kevin S. Litwiler

Senior Vice President of DMPK & Clinical Pharmacology

Mark L. Boys

Senior Vice President of Discovery Chemistry

Rogan Nunn

General Counsel & Secretary

Roberta Alton

Senior Vice President of Clinical Operations

Dylan Hartley

Chief Scientific Officer57$110,000.000.80%

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

8

$4,721.01

Net Sentiment

$4,721.01

Net selling

Most Active

Saccomano Nicholas A

4 transactions

DateInsiderTypeSharesPriceValue
Mar 23, 2026

Saccomano Nicholas A

Direct

Sell86$4.16$357.46
Mar 23, 2026

Leverone Jason A.

Direct

Sell301$4.16$1,251.11
Dec 22, 2025

Saccomano Nicholas A

Direct

Sell87$2.97$258.19
Dec 22, 2025

Leverone Jason A.

Direct

Sell302$2.97$896.25
Sep 22, 2025

Saccomano Nicholas A

Direct

Sell88$2.62$230.87
Sep 22, 2025

Leverone Jason A.

Direct

Sell303$2.62$794.92
Jun 23, 2025

Saccomano Nicholas A

Direct

Sell88$2.38$209.81
Jun 23, 2025

Leverone Jason A.

Direct

Sell303$2.38$722.41

Analysis

Insiders reported 0 buys worth $0.00 and 8 sells worth $4,721.01 over the last 12 months. That adds up to net selling of $4,721.01. Saccomano Nicholas A was the most active insider with 4 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr 5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/AN/A
N/A0 analysts
Net IncomeN/AN/AN/A
N/A0 analysts
EBITN/AN/AN/A
N/A0 analysts

Analysis

Analysis will appear once historical growth or forward estimates are available for this company.

Who manages OKUR?

OnKure Therapeutics, Inc. (OKUR) lists 10 active executives. The top listed executive is Isaac Manke, Senior VP of Business Development & Director.

Are OKUR insiders buying or selling?

Recent insider activity shows net buying of $23.42M.

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