OPKO Health, Inc.

OPKO Health, Inc.

Healthcare

NASDAQ:OPK · NASDAQ Global Select

Market Cap $1.07B Beta 1.49 P/E (TTM) -5.1
$1.42 -2.07%

-$0.03 today

52W Low $0.98High $1.60

Vol 1.74M · Avg 2.58M

EPS (TTM)-$0.28
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-17.8%

avg -9.5%

ROIC

-11.3%

avg -6.1%

ROA

-11.7%

avg -6.6%

Analysis

ROIC is currently the strongest return metric at -11.3% versus its period average of -6.1%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Phillip Frost

Chairman of the Board & CEO$1.45M90$216.23M28.64%

Jane H. Hsiao

Vice Chairman of the Board & Chief Technical Officer$1.36M79$500,000.000.07%

Elias Adam Zerhouni

President & Vice Chairman of the Board$1.36M75$500,000.000.07%

Steven D. Rubin

Executive Vice President of Administration & Director$1.22M66$437,500.000.06%

Adam E. Logal

Senior Vice President, Chief Financial Officer, Chief Accounting Officer & Treasurer$1.19M48$437,500.000.06%

Hans Berner

President of OPKO Health Iberoamerica

Akhtar Ashfaq

Senior Vice President of Clinical Research & Development and Medical Affairs - Opko Renal

Arie Gutman

President of API72

Damien Burke

Chief Executive Officer of EirGen Pharma

Giovanni Abbadessa

Chief Medical Officer of ModeX

Charles W. Bishop

Chief Executive Officer of OPKO Renal74

Gary J. Nabel

Chief Information Officer & Director71$437,500.000.06%

John R. Mascola

Chief Scientific Officer of ModeX$394,340.000.05%

Craig Allen

Chief Executive Officer of Bioreference Health

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

35

$4.09M

Sells

0

$0.00

Net Sentiment

+$4.09M

Net buying

Most Active

FROST PHILLIP MD ET AL

34 transactions

DateInsiderTypeSharesPriceValue
Mar 20, 2026

PAGANELLI JOHN A

Direct

Buy10.0K$1.14$11,350.00
Nov 21, 2025

FROST PHILLIP MD ET AL

Indirect

Buy192.9K$1.34$257,481.45
Nov 21, 2025

FROST PHILLIP MD ET AL

Indirect

Buy191.5K$1.33$254,681.70
Nov 21, 2025

FROST PHILLIP MD ET AL

Indirect

Buy89.4K$1.33$118,421.88
Nov 21, 2025

FROST PHILLIP MD ET AL

Indirect

Buy3.9K$1.32$5,140.08
Nov 21, 2025

FROST PHILLIP MD ET AL

Indirect

Buy102.4K$1.30$133,082.30
Nov 20, 2025

FROST PHILLIP MD ET AL

Indirect

Buy13.7K$1.35$18,446.40
Nov 20, 2025

FROST PHILLIP MD ET AL

Indirect

Buy1.8K$1.35$2,363.17
Nov 20, 2025

FROST PHILLIP MD ET AL

Indirect

Buy24.6K$1.34$32,935.86
Nov 20, 2025

FROST PHILLIP MD ET AL

Indirect

Buy161.8K$1.34$216,027.03

1–10 of 35

Analysis

Insiders reported 35 buys worth $4.09M and 0 sells worth $0.00 over the last 12 months. That adds up to net buying of $4.09M. FROST PHILLIP MD ET AL was the most active insider with 34 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/A+118.6%
+2.3% (15yr)1 analysts
Net IncomeN/AN/AN/A
N/A1 analysts
EBITN/AN/AN/A
N/A1 analysts

Analysis

Recent growth has been strongest in Revenue at +118.6% over three years. Forward estimates point to Revenue at +2.3% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages OPK?

OPKO Health, Inc. (OPK) lists 14 active executives. The top listed executive is Adam E. Logal, Senior Vice President, Chief Financial Officer, Chief Accounting Officer & Treasurer.

Are OPK insiders buying or selling?

Recent insider activity shows net buying of $33.40M.

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