Septerna, Inc.

Healthcare

NASDAQ:SEPN · NASDAQ Global Select

Market Cap $1.62B Beta 2.38 P/E (TTM) -44.6
$35.95 +5.64%

+$1.92 today

52W Low $9.85High $36.26

Vol 0.48M · Avg 0.31M

EPS (TTM)-$0.81
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-12.8%

avg -10.2%

ROIC

-15.8%

avg -8.1%

ROA

-8.2%

avg -5.2%

Analysis

ROA is currently the strongest return metric at -8.2% versus its period average of -5.2%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Jeffrey T. Finer

Co-Founder, Chief Executive Officer & Director$1.04M59$400,000.000.89%

Elizabeth Bhatt

President & Chief Operating Officer$735,000.0058$178,209.000.40%

Gilbert Labrucherie

Chief Financial Officer$711,727.0054$125,000.000.28%

Samira Shaikhly

Chief People Officer$536,487.0056$6,728.000.01%

Jae Kim FACC

Chief Medical Officer$486,288.0056$125,000.000.28%

George Xu

Senior Director of Corporate Development & Portfolio Strategy

Mark A. Wilson

Chief Legal Officer54$165,000.000.37%

Arthur Christopoulos BPHARM

Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board

Robert J. Lefkowitz

Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board82

Richard Hansen

Vice President of Technology

Patrick Sexton

Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

12

$2.78M

Net Sentiment

$2.78M

Net selling

Most Active

Shaikhly Samira

6 transactions

DateInsiderTypeSharesPriceValue
Jun 1, 2026

Shaikhly Samira

Direct

Sell1.7K$27.78$47,231.27
Jun 1, 2026

Shaikhly Samira

Direct

Sell1.3K$28.79$38,755.11
Jun 1, 2026

Shaikhly Samira

Direct

Sell2.9K$29.66$85,696.12
May 26, 2026

Shaikhly Samira

Direct

Sell11.8K$30.06$354,656.14
Apr 15, 2026

Bhatt Elizabeth

Direct

Sell2.6K$23.76$61,123.67
Apr 15, 2026

Bhatt Elizabeth

Direct

Sell1.1K$25.24$27,788.58
Apr 15, 2026

Bhatt Elizabeth

Direct

Sell326$25.86$8,431.11
Mar 2, 2026

Shaikhly Samira

Direct

Sell4.1K$27.51$112,496.27
Mar 2, 2026

Shaikhly Samira

Direct

Sell66.4K$28.14$1,867,342.00
Feb 18, 2026

Bhatt Elizabeth

Direct

Sell2.2K$28.46$62,610.68

1–10 of 12

Analysis

Insiders reported 0 buys worth $0.00 and 12 sells worth $2.78M over the last 12 months. That adds up to net selling of $2.78M. Shaikhly Samira was the most active insider with 6 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/AN/A
+14.3% (5yr)3 analysts
Net IncomeN/AN/AN/A
N/A3 analysts
EBITN/AN/AN/A
N/A3 analysts

Analysis

Forward estimates point to Revenue at +14.3% (5yr), giving you a quick read on expected growth from here.

Who manages SEPN?

Septerna, Inc. (SEPN) lists 11 active executives. The top listed executive is George Xu, Senior Director of Corporate Development & Portfolio Strategy.

Are SEPN insiders buying or selling?

Recent insider activity shows net buying of $35.42M.

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