Sionna Therapeutics, Inc.

Sionna Therapeutics, Inc.

Healthcare

NASDAQ:SION · NASDAQ Global Market

Market Cap $1.62B Beta 1.29 P/E (TTM) -18.9
$35.92 -0.36%

-$0.13 today

52W Low $13.51High $48.45

Vol 0.19M · Avg 0.40M

EPS (TTM)-$1.90
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-24.5%

avg 28.0%

ROIC

-28.2%

avg -58.3%

ROA

-23.1%

avg -48.3%

Analysis

ROA is currently the strongest return metric at -23.1% versus its period average of -48.3%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Michael Cloonan

President, Chief Executive Officer & Director$1.03M54$436,100.000.97%

Elena H. Ridloff

Chief Financial Officer$771,602.0046$165,440.000.37%

Charlotte McKee

Chief Medical Officer$647,922.0061$155,700.000.34%

Caroline Stark Beer

Chief Business Officer$268,113.0047$139,340.000.31%

Greg Hurlbut

Co-Founder & Senior Vice President of Discovery Research

Mark Munson

Co-founder & Senior Vice President of Medicinal Chemistry

Andy Chu

Vice President of Information & Technology

Kenneth A. Lock

Chief Commercial Officer52$2.67M5.92%

Jennifer Fitzpatrick

Chief Legal Officer49$50,935.000.11%

Mara Furlow

Senior Vice President of Global Regulatory Affairs & Quality

Meghan Bagshaw

Vice President of Programs, Portfolio & Operations

Sarah J. Spencer

Vice President of Corporate Communications

Vanya Sagar

Chief People Officer50

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

1

$950,400.00

Sells

153

$155.94M

Net Sentiment

$154.99M

Net selling

Most Active

Booth Bruce

50 transactions

DateInsiderTypeSharesPriceValue
May 27, 2026

Thompson Peter A.

Indirect

Sell101$44.49$4,493.49
May 27, 2026

ORBIMED ADVISORS LLC

Indirect

Sell101$44.49$4,493.49
May 11, 2026

ORBIMED ADVISORS LLC

Indirect

Sell184.6K$46.22$8,534,014.58
May 11, 2026

Thompson Peter A.

Indirect

Sell184.6K$46.22$8,534,014.58
May 8, 2026

ORBIMED ADVISORS LLC

Indirect

Sell59.8K$44.58$2,664,412.86
May 8, 2026

Thompson Peter A.

Indirect

Sell59.8K$44.58$2,664,412.86
May 7, 2026

Thompson Peter A.

Indirect

Sell48.5K$44.61$2,165,637.06
May 7, 2026

ORBIMED ADVISORS LLC

Indirect

Sell48.5K$44.61$2,165,637.06
Apr 18, 2026

ORBIMED ADVISORS LLC

Indirect

Sell2.9K$44.52$131,244.96
Apr 18, 2026

Thompson Peter A.

Indirect

Sell2.9K$44.52$131,244.96

1–10 of 154

Analysis

Insiders reported 1 buys worth $950,400.00 and 153 sells worth $155.94M over the last 12 months. That adds up to net selling of $154.99M. Booth Bruce was the most active insider with 50 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A6 analysts
RevenueN/AN/AN/A
N/A4 analysts
Net IncomeN/AN/AN/A
N/A4 analysts
EBITN/AN/AN/A
N/A4 analysts

Analysis

Analysis will appear once historical growth or forward estimates are available for this company.

Who manages SION?

Sionna Therapeutics, Inc. (SION) lists 13 active executives. The top listed executive is Charlotte McKee, Chief Medical Officer.

Are SION insiders buying or selling?

Recent insider activity shows net selling of $105.48M.

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