Summit Therapeutics Inc.

Summit Therapeutics Inc.

Healthcare

NASDAQ:SMMT · NASDAQ Global Market

Market Cap $10.86B Beta -1.31 P/E (TTM) -10.3
$14.01 +7.11%

+$0.93 today

52W Low $12.55High $30.98

Vol 9.81M · Avg 4.43M

EPS (TTM)-$1.36
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-220.8%

avg -42.2%

ROIC

-216.3%

avg -90.6%

ROA

-193.6%

avg -75.6%

Analysis

ROA is currently the strongest return metric at -193.6% versus its period average of -75.6%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Mahkam Zanganeh

Co-CEO, President & Director$1.03M56$573.88M74.01%

Manmeet Singh Soni

Chief Operating Officer, Chief Financial Officer & Director$1.03M48$3.12M0.40%

Robert W. Duggan

Co-CEO & Executive Chairman$172,376.0081$573.88M74.01%

Bilal Piperdi

Chief Medical Officer

Howard Jack West

Vice President of Clinical Development

Nathan LiaBraaten

Senior Director of Investor Relations

Laura Q. Chow

Senior Vice President of Clinical Development

Urte Gayko

Chief Regulatory, Quality & Pharmacovigilance Officer55$400,000.000.05%

Bhaskar Anand

Chief Accounting Officer49$30,000.00<0.01%

Dave Gancarz

Chief Business & Strategy Officer

Kay Elizabeth Davies

Co-Founder, Chairman of Scientific Advisory Board and Scientific Advisor75

Allen S. Yang

Head of R&D Strategy58

Wang Clow Fong

Chief Biometrics Officer68$91,096.000.01%

Robert LaCaze

Chief Commercial Officer$573.88M74.01%

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

13

$126.59M

Sells

0

$0.00

Net Sentiment

+$126.59M

Net buying

Most Active

DUGGAN ROBERT W

5 transactions

DateInsiderTypeSharesPriceValue
Jun 12, 2026

DUGGAN ROBERT W

Direct

Buy3.81M$13.12$49,987,200.00
Jun 12, 2026

Zanganeh Mahkam

Indirect

Buy3.81M$13.12$49,987,200.00
Jun 4, 2026

Zanganeh Mahkam

Indirect

Buy100.0K$14.60$1,460,000.00
Jun 4, 2026

DUGGAN ROBERT W

Indirect

Buy100.0K$14.60$1,460,000.00
Jun 4, 2026

Soni Manmeet Singh

Direct

Buy25.0K$14.46$361,500.00
Jun 4, 2026

Soni Manmeet Singh

Direct

Buy25.0K$14.43$360,750.00
Oct 21, 2025

Xia Yu

Indirect

Buy533.6K$18.74$9,999,982.58
Oct 21, 2025

DUGGAN ROBERT W

Indirect

Buy26.7K$18.74$499,983.20
Oct 21, 2025

Zanganeh Mahkam

Indirect

Buy26.7K$18.74$499,983.20
Sep 11, 2025

Zanganeh Mahkam

Indirect

Buy5.0K$18.07$90,350.00

1–10 of 13

Analysis

Insiders reported 13 buys worth $126.59M and 0 sells worth $0.00 over the last 12 months. That adds up to net buying of $126.59M. DUGGAN ROBERT W was the most active insider with 5 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A5 analysts
RevenueN/AN/A-12.2%
+70.8% (15yr)6 analysts
Net IncomeN/AN/AN/A
N/A6 analysts
EBITN/AN/AN/A
N/A6 analysts

Analysis

Recent growth has been strongest in Revenue at -12.2% over three years. Forward estimates point to Revenue at +70.8% (15yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages SMMT?

Summit Therapeutics Inc. (SMMT) lists 14 active executives. The top listed executive is Mahkam Zanganeh, Co-CEO, President & Director.

Are SMMT insiders buying or selling?

Recent insider activity shows net buying of $1.52B.

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