Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc.

Healthcare

NASDAQ:SYRE · NASDAQ Capital Market

Market Cap $4.88B Beta 3.06 P/E (TTM) -155.8
$80.79 +0.02%

+$0.02 today

52W Low $13.93High $84.43

Vol 0.79M · Avg 1.16M

EPS (TTM)-$0.52
Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management

ROE

-21.7%

avg -78.6%

ROIC

-29.1%

avg -66.7%

ROA

-20.0%

avg -58.4%

Analysis

ROA is currently the strongest return metric at -20.0% versus its period average of -58.4%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Cameron Turtle DPHIL

Chief Executive Officer & Director$1.15M36$608,983.001.01%

Sheldon Sloan

Chief Medical Officer$778,560.0067$313,334.000.52%

Scott L. Burrows

Chief Financial Officer$758,800.0049$374,857.000.62%

Heidy Abreu King-Jones

Chief Legal Officer & Corporate Secretary$758,800.0043$140,000.000.23%

James Myers

Vice President of Quality & Compliance

Melissa Cooper

Senior Vice President of People

Janet Gunzner-Toste

Senior Vice President of Operations

Justin LaFountaine

Senior Vice President of Corporate Development

Brian Connolly

Chief Technical Officer

Eric McIntyre

Vice President of Finance & Investor Relations

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

0

$0.00

Sells

44

$20.71M

Net Sentiment

$20.71M

Net selling

Most Active

Turtle Cameron

22 transactions

DateInsiderTypeSharesPriceValue
Jun 3, 2026

Sloan Sheldon

Direct

Sell8.3K$75.00$624,975.00
Jun 1, 2026

Turtle Cameron

Direct

Sell3.6K$69.40$246,855.80
Jun 1, 2026

Turtle Cameron

Direct

Sell8.1K$70.50$574,504.50
Jun 1, 2026

Turtle Cameron

Direct

Sell3.3K$71.38$235,125.72
Jun 1, 2026

Burrows Scott L

Direct

Sell1.8K$69.75$125,619.75
Jun 1, 2026

Burrows Scott L

Direct

Sell2.6K$70.77$183,931.23
Jun 1, 2026

Burrows Scott L

Direct

Sell3.1K$72.06$223,386.00
May 8, 2026

HENDERSON MICHAEL THOMAS

Direct

Sell2.4K$72.57$174,458.28
May 8, 2026

HENDERSON MICHAEL THOMAS

Direct

Sell33.5K$73.72$2,470,578.36
May 8, 2026

HENDERSON MICHAEL THOMAS

Direct

Sell24.8K$74.76$1,855,094.64

1–10 of 44

Analysis

Insiders reported 0 buys worth $0.00 and 44 sells worth $20.71M over the last 12 months. That adds up to net selling of $20.71M. Turtle Cameron was the most active insider with 22 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A3 analysts
RevenueN/AN/A-13.9%
+33.2% (12yr)4 analysts
Net IncomeN/AN/AN/A
N/A4 analysts
EBITN/AN/AN/A
N/A4 analysts

Analysis

Recent growth has been strongest in Revenue at -13.9% over three years. Forward estimates point to Revenue at +33.2% (12yr), giving you a quick check on whether expectations are accelerating or cooling.

Who manages SYRE?

Spyre Therapeutics, Inc. (SYRE) lists 10 active executives. The top listed executive is Scott L. Burrows, Chief Financial Officer.

Are SYRE insiders buying or selling?

Recent insider activity shows net buying of $48.42M.

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