Xilio Therapeutics, Inc.

Xilio Therapeutics, Inc.

Healthcare

NASDAQ:XLO · NASDAQ Global Select

Market Cap $55.89M Beta -0.09 P/E (TTM) -43.4
$8.48 +4.01%

+$0.32 today

52W Low $6.47High $12.74

Vol 0.04M · Avg 0.05M

EPS (TTM) -$0.19Biotechnology

Management

Put operating results in leadership context

Review returns on capital, executive background, insider transactions, and growth quality to judge whether management is compounding value well.

Return Metrics

ROE, ROIC & ROA over time

Management
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ROE

-99.3%

avg 34.0%

ROIC

-42.1%

avg -114.1%

ROA

-22.6%

avg -72.5%

Analysis

ROA is currently the strongest return metric at -22.6% versus its period average of -72.5%. 0 of 3 return metrics are above their quality threshold, which helps indicate how efficiently the company turns capital and assets into profit.

Management

Key executives, compensation & ownership

Management
NameTitleCompensationTenureAgeShares OwnedOwnership %

Rene Russo BCPS

President, Chief Executive Officer & Director$1.16M51$88,500.001.35%

Christopher Frankenfield

Chief Financial Officer & Chief Operating Officer$941,594.0044$24,766.000.38%

Katarina Luptakova

Chief Medical Officer$691,670.0050$33,250.000.51%

Uli Bialucha

Chief Scientific Officer

Ruth du Moulin

Senior Vice President of Medical Affairs

Scott Coleman

Chief Development Officer

Kevin Brennan

Senior Vice President of Finance & Accounting56$5,000.000.08%

Nathan McBride

Chief Information Officer

Caroline Hensley

Chief Legal Officer

Insider Trading

SEC Form 4 transactions — last 12 months

Management

Buys

3

$61,538.90

Sells

2

$5,696.18

Net Sentiment

+$55,842.72

Net buying

Most Active

Shannon James Samuel

2 transactions

DateInsiderTypeSharesPriceValue
Mar 26, 2026

Shannon James Samuel

Direct

Buy5.0K$8.79$43,950.00
Feb 13, 2026

GILEAD SCIENCES, INC.

Direct

Buy3.74M$0.00$373.90
Jan 2, 2026

Brennan Kevin M.

Direct

Sell1.8K$0.64$1,174.48
Jan 2, 2026

Frankenfield Christopher James

Direct

Sell7.0K$0.64$4,521.70
Jun 17, 2025

Shannon James Samuel

Direct

Buy25.0K$0.69$17,215.00

Analysis

Insiders reported 3 buys worth $61,538.90 and 2 sells worth $5,696.18 over the last 12 months. That adds up to net buying of $55,842.72. Shannon James Samuel was the most active insider with 2 transactions.

Growth Analysis

Historical CAGR & forward analyst estimates

Metric 10yr 5yr3yr Fwd Est.
EPSN/AN/AN/A
N/A1 analysts
RevenueN/AN/AN/A
N/A1 analysts
Net IncomeN/AN/AN/A
N/A1 analysts
EBITN/AN/AN/A
N/A1 analysts

Analysis

Analysis will appear once historical growth or forward estimates are available for this company.

Who manages XLO?

Xilio Therapeutics, Inc. (XLO) lists 9 active executives. The top listed executive is Christopher Frankenfield, Chief Financial Officer & Chief Operating Officer.

Are XLO insiders buying or selling?

Recent insider activity shows net buying of $31.11M.

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